The band was launched in 2004 after winning the Grand Prize of the Red Horse Muziklaban 2004. Their debut self-titled album, Mayonnaise was launched with their 1st single, "Jopay" which was released by Sony Music Philippines. Jopay is a reference of a former member of the Sexbomb Dancers. Their next single was "Bakit Part 2" which became a radio airplay hit.
Their follow-up 2nd album, Pa'no Nangyari Yun? was released in 2006 with their carrier single, "Salamin". The same year, the band also covered the song, '"Ipagpatawad Mo", originally from VST and Company. The song was included in their collaboration album, Hopia Mani Popcorn.
In 2008, Mayonnaise released their 3rd album, Tersera which was launched with their singles, "Singungaling", "Torres" and "Sakto". The band released their 4th album, Pula in 2010 with the carrier single, "Sa Pula, Sa Puti".
The group also sang the TV theme song of ABS-CBN 2's reality show, The Biggest Loser: Pinoy Edition entitled "Sabay Tayo" in 2011.
